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The induced fit mechanism and conformational changes of some enzymes are reviewed. Although it is maintained in the literature that induced fit provides specificity, one simple model for induced fit does not provide specificity, according to the usual definition of specificity: the discrimination by an enzyme between the reactions of two competing substrates. Discrimination is measured by the r...
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Fat storage-inducing transmembrane (FIT or FITM) proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. At the molecular level, the sole relevant interaction is that FITMs directly bind to triacyglycerol and diacylglycerol, but how they function at the molecular level is not known. Saccharomyces cerevisiae has two FI...
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The investigation of the subcellular localization, dynamics and interaction of proteins and protein complexes in prokaryotes is complicated by the small size of the cells. Super-resolution microscopy (SRM) comprise various new techniques that allow light microscopy with a resolution that can be up to ten-fold higher than conventional light microscopy. Application of SRM techniques to living pro...
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Research in cell biology demands advanced microscopy techniques such as confocal fluorescence microscopy (FM), super-resolution microscopy (SRM) and transmission electron microscopy (TEM). Correlative light and electron microscopy (CLEM) is an approach to combine data on the dynamics of proteins or protein complexes in living cells with the ultrastructural details in the low nanometre scale. To...
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ژورنال
عنوان ژورنال: Materials Today
سال: 2011
ISSN: 1369-7021
DOI: 10.1016/s1369-7021(11)70131-6